Beilstein J. Org. Chem.2020,16, 1022–1050, doi:10.3762/bjoc.16.91
Laila F. Awad Mohammed Salah Ayoup Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt 10.3762/bjoc.16.91 Abstract Recent advances in the chemistry of peptides containing fluorinatedphenylalanines (Phe) represents a hot topic in drug research
over the last few decades. ᴅ- or ʟ-fluorinatedphenylalanines have had considerable industrial and pharmaceutical applications and they have been expanded also to play an important role as potential enzyme inhibitors as well as therapeutic agents and topography imaging of tumor ecosystems using PET
. Incorporation of fluorinated aromatic amino acids into proteins increases their catabolic stability especially in therapeutic proteins and peptide-based vaccines. This review seeks to summarize the different synthetic approaches in the literature to prepare ᴅ- or ʟ-fluorinatedphenylalanines and their
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Graphical Abstract
Figure 1:
Categories I–V of fluorinated phenylalanines.